R M Brown Selected Research

Pyruvate Dehydrogenase Complex Deficiency Disease

3/2008	A putative exonic splicing enhancer in exon 7 of the PDHA1 gene affects splicing of adjacent exons.
9/2006	Pyruvate dehydrogenase E3 binding protein (protein X) deficiency.
10/2004	Pyruvate dehydrogenase deficiency presenting as dystonia in childhood.
1/2000	Mutations in the X-linked pyruvate dehydrogenase (E1) alpha subunit gene (PDHA1) in patients with a pyruvate dehydrogenase complex deficiency.

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R M Brown Research Topics

Disease

4	Pyruvate Dehydrogenase Complex Deficiency Disease 03/2008 - 01/2000
3	Lactic Acidosis 09/2006 - 01/2000
2	Leigh Disease (Leigh's Disease) 01/2004 - 06/2001
2	Urinary Bladder Neoplasms (Bladder Cancer) 09/2001 - 01/2001
2	Disease Progression 09/2001 - 01/2001
1	Substance-Related Disorders (Drug Abuse) 01/2016
1	Fibrosis (Cirrhosis) 10/2011
1	Pain (Aches) 01/2007
1	Osteoarthritis 01/2007
1	Dystonia (Limb Dystonia) 10/2004
1	Cytochrome-c Oxidase Deficiency 01/2004
1	Retinoblastoma (Glioblastoma, Retinal) 09/2001
1	Carcinoma in Situ 01/2001
1	Neoplasms (Cancer) 01/2001
1	AIDS-Related Complex (ARC) 01/2001
1	Hypersensitivity (Allergy) 06/2000
1	Metabolic Diseases (Metabolic Disease) 01/2000
1	Delirium 01/2000
1	Poisoning 01/2000

Drug/Important Bio-Agent (IBA)

3	Oxidoreductases (Dehydrogenase)IBA 09/2006 - 01/2000
3	Pyruvic Acid (Pyruvate)IBA 09/2006 - 01/2000
2	Carrier Proteins (Binding Protein)IBA 09/2006 - 01/2004
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 01/2004 - 06/2001
2	Proteins (Proteins, Gene)FDA Link 01/2004 - 06/2000
1	Cocaine (Cocaine HCl)IBA 01/2016
1	Antiviral Agents (Antivirals)IBA 10/2011
1	Nonsense Codon (Nonsense Mutation)IBA 03/2008
1	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2007
1	Celecoxib (Celebrex)FDA Link 01/2007
1	Pharmaceutical PreparationsIBA 01/2007
1	Dihydrolipoamide Dehydrogenase (Lipoamide Dehydrogenase)IBA 09/2006
1	Levodopa (L Dopa)FDA LinkGeneric 10/2004
1	Carbidopa (Lodosyn)FDA LinkGeneric 10/2004
1	RNA Splice SitesIBA 01/2004
1	Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)IBA 01/2004
1	Surf-1 proteinIBA 06/2001
1	Cadherins (E-Cadherin)IBA 01/2001
1	CarbonIBA 01/2001
1	MetalsIBA 01/2001
1	GraphiteIBA 01/2001
1	Interferon-gamma (Interferon, gamma)IBA 06/2000
1	Tuberculin (PPD)IBA 06/2000
1	PhysostigmineIBA 01/2000
1	BenzodiazepinesIBA 01/2000
1	pyruvate dehydrogenase E1alpha subunitIBA 01/2000
1	Cholinergic Antagonists (Anticholinergics)IBA 01/2000

Therapy/Procedure

2	Therapeutics 10/2011 - 01/2001
1	Cystectomy 09/2001
1	Lasers (Laser) 01/2001